Project Coordinator: Aissatou Toure (Senegal)
Target disease: Malaria
Partners: Institut Pasteur (France), Institut Pasteur de Dakar (Senegal), Institut Pasteur de Madagascar (Madagascar)
Budget: € 192,060
Duration of project: April 2011-April 2013

The project aims to optimise and standardise a “new” functional assay developed,  the Antibody Dependant Respiratory Burst (ADRB) assay detected by chemiluminescence, which has been correlated with clinical protection against malaria. It will compare ADRB results with those of other commonly used functional assays such as the growth inhibition assay (GIA). The ADRB assay will be used as a tool to evaluate the level of malaria immunity in different endemic populations and to validate merozoite surface antigen vaccine candidates.