Improved treatment and clinical management of poverty-related diseases

The purpose of this Call for Proposals is to invest in projects that evaluate new or significantly improved drugs or drug regimens in humans or optimise the efficacy and use of existing therapeutics for any of the poverty-related diseases, including co-infections of poverty-related infectious diseases, within our scope.

AMBITION
High-dose ambisome on a fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: a randomised controlled non-inferiority trial

London School of Hygiene & Tropical Medicine (LSHTM), United Kingdom with partners from Botswana, France, Malawi, South Africa, Uganda, United Kingdom, and Zimbabwe
Project Coordinator: Dr Joseph Jarvis, LSHTM, United Kingdom
Starting date:
 1 January 2017
Duration: 48 months
Grant amount: EUR 9,990,712
Grant agreement: TRIA-2015-1092

CHAPAS 4
Children with HIV in Africa – Pharmacokinetics and acceptability of simple antiretroviral regimens

University of Zimbabwe, College of Health Sciences (UZCHS), Zimbabwe with partners from the Netherlands, South Africa, Uganda, United Kingdom, and Zambia
Project coordinator: Dr Mutsa Bwakura-Dangarembizi, UZCHS, Zimbabwe
Starting date: 1 July 2017
Duration: 66 months
Grant amount: EUR 7,556,256
Grant agreement: TRIA-2015-1078

IMPROVE
IPTp with dihydroartemisinin-piperaquine and azithromycin for malaria, sexually transmitted and reproductive tract infections in pregnancy in high sulphadoxine-pyrimethamine resistance areas in Kenya, Malawi, and Tanzania

Liverpool School of Tropical Medicine (LSTM), United Kingdom with partners from Denmark, Finland, Kenya, Malawi, Norway, Tanzania and United Kingdom
Project coordinator: Prof. Feiko ter Kuile, LSTM, United Kingdom
Starting date: 1 December 2016
Duration: 48 months
Grant amount: EUR 7,389,049
Grant agreement: TRIA-2015-1076
Go to webpage

IMPROVE-2
IPTp with dihydroartemisinin-piperaquine and azithromycin for malaria, sexually transmitted and reproductive tract infections in HIV-infected pregnancy in Kenya and Malawi: a multicentre 3-arm placebo-controlled trial

Liverpool School of Tropical Medicine (LSTM), United Kingdom with partners from Kenya, Malawi, and United Kingdom
Project coordinator: Prof. Feiko ter Kuile, LSTM, United Kingdom
Starting date: 1 July 2017
Duration: 41 months
Grant amount: EUR 3,200,000
Grant agreement: TRIA-2015-1076b
* This project is funded through the UK Joint Global Health Trials scheme (a UK partnership of the Department for International Development, the Medical Research Council, and the Wellcome Trust).

PanACEA
PanACEA, a drug development programme to shorten and simplify treatment of tuberculosis

Stichting Katholieke Universiteit [Foundation Catholic University) (RUNMC), Netherlands with partners from Gabon, Germany, Malawi, Mozambique, South Africa, Switzerland, Tanzania, Uganda, and United Kingdom
Project coordinator: Professor Martin Boeree, RUNMC, Netherlands)
Starting date: 1 March 2017
Duration: 60 months
Grant amount: EUR 11,394,775
Grant agreement: TRIA-2015-1102

PanACEA website