| Target disease |
Title |
Grantee |
Status |
| HIV/AIDS |
CHAPAS trial: Children with HIV in Africa - Pharmacokinetics and Adherence of Simple Antiretroviral Regimens |
Chifumbe Chintu |
Completed |
| HIV/AIDS |
Strengthening of long term clinical and laboratory research capacity, cohort development, and collection of epidemiological and social science baseline data in Uganda and Malawi to prepare for future HIV vaccine trials |
Pontiano Kaleebu |
Completed |
| HIV/AIDS |
Africa-European HIV Vaccine Development Network (AfrEVacc) |
Jonathan Weber |
Ongoing |
| HIV/AIDS |
Capacity development and strengthening in preparation for HIV vaccine trials in Tanzania and Burkina Faso (HIVTAB) |
Saidi Kapiga |
Completed |
| HIV/AIDS |
HIV vaccine trial capacity building in Tanzania and Mozambique by continued exploration of optimal DNA priming and MVA boosting strategies (TaMoVac) |
Muhammad Bakari |
Ongoing |
| HIV/AIDS |
Preparing for adolescent HIV vaccine trials in South Africa (CATSA) |
Linda-Gail Bekker |
Completed |
| HIV/AIDS (PMTCT) |
Back-up with Combivir (AZT/3TC) or single dose Truvada (FTC/TDF) in order to avoid Non Nucleoside Reverse Transcriptase Inhibitor (NNRTI) resistance after single dose Nevirapine for the prevention of mother-to-child transmission (MTCT) (ComTru Study) |
Teresa Katzenstein |
Ongoing |
| HIV/AIDS (PMTCT) |
Improving the balance between efficacy and development of resistance in women receiving single dose nevirapine (VIramune®, NVP) for the prevention of mother-to-child transmission in Tanzania & Zambia (VITA studies) |
Elton Kisanga |
Ongoing |
| HIV/AIDS (PMTCT) |
Impact of HAART during Pregnancy and Breastfeeding on MTCT and Mother's Health: The Kesho Bora Study |
Marie Louise Newell |
Completed |
| HIV/AIDS (PMTCT) |
Development of an infant vaccine against mother-to-child transmission of HIV-1 through breast milk (PedVacc) |
Tomás Hanke |
Ongoing |
| HIV/AIDS (PMTCT) |
Efficacy and safety of infant peri-exposure prophylaxis with lamivudine to prevent HIV-1 transmission by breastfeeding (PROMISE-PEP) |
Philippe van de Perre |
Ongoing |
| HIV/AIDS (microbicides) |
Preparing for Phase III vaginal microbicide trials in Rwanda and Kenya: Preparedness studies, capacity building, and strengthening of medical referral systems |
Janneke van de Wijgert |
Completed |
| HIV/AIDS (microbicides) |
Site preparation and capacity strengthening for trials of vaginal microbicides in Tanzania and Uganda |
Richard Hayes |
Completed |
| HIV/AIDS (microbicides) |
Establishing HIV microbicide clinical trial capacity in Mozambique and expanding and existing site in South Africa |
Sheena McCormack |
Completed |
| HIV/AIDS (microbicides) |
Novel biomarkers to measure safety of microbicides |
Kishor Mandaliya |
Ongoing |
| HIV/AIDS |
Building HIV vaccine trial capacity in Tanzania and Mozambique using a HIV DNA-MVA vaccine concept delivered by novel technologies |
Eligius Lyamuya |
Ongoing |
| HIV/AIDS |
International phase 3 randomised clinical trial to study two once-a-day simplified strategies after an initial antiretroviral therapy among HIV-infected infants in Africa (MONOD) |
Valériane Leroy |
Ongoing |
| HIV/AIDS |
Evaluating options for second-line therapy in patients failing a first-line 2NRTI + NNRTI regimen in Africa (EARNEST) |
Peter Mugyenyi |
Ongoing |
| HIV/AIDS |
Developing research capacity and networking through the evaluation of two second-line antiretroviral HIV treatment strategies in sub-Saharan Africa |
Eric Delaporte |
Ongoing |
| HIV/AIDS |
Children with HIV in Africa Pharmacokinetics and Acceptability/Adherence of Simple Antiretroviral Regimens (CHAPAS-3) |
Veronica Mulenga |
Ongoing |
| HIV/AIDS |
Nutritional support for Africans starting antiretroviral therapy (NUSTART) |
Suzanne Filteau |
Ongoing |
| HIV/AIDS |
Prevention of early mortality by presumptive tuberculosis treatment in HIV-infected patients initiating antiretroviral therapy |
Joseph Marie Albert Lange |
Ongoing |
| Tuberculosis |
The evaluation of Mycobacterium tuberculosis specific host cytokine signatures in whole blood culture supernatants as diagnostic biomarkers for active TB infection |
Gerhard Walzl |
Ongoing |
| Tuberculosis |
Evaluation of new and emerging diagnostics for childhood tuberculosis in high burden countries (TB CHILD) |
Fred Lwilla |
Ongoing |
| Tuberculosis |
Evaluation of multiple novel and emerging technologies for TB diagnosis, in smear-negative and HIV-infected persons, in high burden countries (the TB-NEAT study) |
Keertan Dheda |
Ongoing |
| Tuberculosis |
Phase II double-blind, randomised, placebo-controlled study to evaluate the safety and immunogenicity of H1, an adjuvanted TB subunit vaccine in HIV-infected, BCG-vaccinated adults with CD4+ lymphocyte counts greater than 350 cells/mm3 |
Gavin J. Churchyard |
Ongoing |
| Tuberculosis |
Conduct of ICH-GCP level phase II TB vaccine trials in high risk populations in Africa |
Mark Doherty |
Ongoing |
| Tuberculosis |
A Phase IIb efficacy trial to evaluate the protective efficacy of a booster MVA85A vaccination in healthy, HIV-infected adults in South Africa, Senegal and The Gambia |
Martin Ota |
Ongoing |
| Tuberculosis |
A new TB vaccine for African infants |
Hassan Mahomed |
Ongoing |
| Tuberculosis |
Rapid Evaluation of Moxifloxacin in Tuberculosis (PanACEA - REMoxTB) |
Stephen Gillespie |
Ongoing |
| Tuberculosis |
Clinical studies with high dose rifampicin & development of clinical research capacity in Africa (PanACEA – HIGHRIF) |
Martin Boeree |
Ongoing |
| Tuberculosis |
Evaluation of a novel TB drug (SQ109) to shorten and simplify TB treatment (PanACEA - SQ109) |
Michael Hoelscher |
Ongoing |
| Tuberculosis |
Optimisation of tuberculosis and HIV co-treatment in Africa: Pharmacokinetic and pharmacogenetic aspects on drug-drug interactions between rifampicin and efavirenz |
Leif Bertilsson |
Ongoing |
| Tuberculosis |
Prospective epidemiological studies of TB in neonates and adolescents in Karemo Division, Siaya district, Western Kenya, in preparation for future clinical trials
|
Anja van‘t Hoog |
Ongoing |
| Tuberculosis |
Towards conducting phase III trials of novel TB vaccines in Ugandan infants and adolescents |
Philippa Musoke |
Ongoing |
| Tuberculosis |
Surrogate markers to predict the outcome of antituberculosis therapy |
Paul van Helden |
Completed |
| Tuberculosis |
Capacity building for the conduct of ICH-GCP level TB vaccine trials in high risk populations in Ethiopia and East Africa |
Abraham Aseffa |
Ongoing |
| Tuberculosis |
Rapid Evaluation of Moxifloxacin in Tuberculosis – REMoxTB |
Stephen Gillespie |
Ongoing |
| Tuberculosis |
A controlled clinical trial to evaluate high dose rifapentine and a quinoline in the treatment of pulmonary tuberculosis |
Amina Jindani |
Ongoing |
| Tuberculosis |
Determining the optimal doses of antiretroviral and antituberculous medications when used in combination for the treatment of HIV/TB in co-infected patients |
Concepta Merry |
Completed |
| Malaria |
Fostering research capacity, networking and project management through phase I-IIB clinical trials of candidate malaria vaccine GMZ2 |
Dawit Ejigu |
Ongoing |
| Malaria |
Integrating capacity building and networking in the design and conduct of phase I and II clinical trials of viral vectored candidate malaria vaccines in East and West African children and infants |
Egeruan Babatunde Imoukhuede |
Ongoing |
| Malaria (in pregnancy) |
Antimalarial treatment for African pregnant women |
Umberto D'Alessandro |
Ongoing |
| Malaria (in pregnancy) |
Evaluation of alternative antimalarial drugs to sulfadoxine-pyrimethamine for intermittent preventive treatment in pregnancy (IPTp) in the context of insecticide treated nets |
Clara Menéndez |
Ongoing |
| Malaria (in pregnancy) |
Intermittent preventive therapy with SP for the prevention of malaria in pregnancy: Regimen optimisation studies in Africa |
Feiko ter Kuile |
Ongoing |
| Malaria |
West African Network for Clinical Trials of Antimalarial Drugs (WANCAM) |
Abdoulaye Djimde |
Ongoing |
| Malaria |
Evaluating pharmacokinetic interactions between ACTs and antiretrovirals and appropriate age based dosing strategies for ACTs |
Victor Mwapasa |
Ongoing |
| Malaria |
Evaluation of 4 artemisinin-based combinations for treating uncomplicated malaria in African children |
Umberto D'Alessandro |
Completed |
| Malaria |
Artesunate for severe malaria in African children |
Peter Kremsner |
Ongoing |
