Project Coordinator: Eugene Kinyanda (Uganda)
Target disease: HIV
Partners: Medical Research Council Programme on AIDS - Uganda Virus Research Institute (MRC/UVRI, Uganda)
Budget: € 195,156
Duration of project: April 2011-April 2013

The study aims to answer the following questions: What is the prevalence of the mental health problems of major depressive disorder (MDD) and maladaptive coping style (MACS) among HIV-infected patients in the African setting of Uganda, and what is the incidence of MDD in HIV/AIDS? Do the mental health problems of MDD and MACS significantly impact on HIV disease progression in the African socio-cultural environment in Uganda including via non-adherence to ART? What would be the potential impact of the mental health covariates MDD and MACS on HIV disease progression on the DART trial results under a range of possible differential treatment effects in the subgroups of patients with and without psychological problems?