Project Coordinator: Godwin Nchinda (Cameroon)
Target disease: HIV
Partners: International Reference Centre Chantal Biya (CIRCB, Cameroon), Ruhr University Bochum (Germany), the Rockefeller University (United States)
Budget: € 199,036
Duration of project: March 2011-March 2013

To examine if a DC targeted consensus B HIV gag p24 protein vaccine could recall in vitro pre-existing gag  specific T cells in PBMCs of subjects chronically infected with unrelated HIV-1 strains prevalent in Africa and to compare in terms of magnitude, breadth, and depth T cell responses recalled in vitro in peripheral blood mononuclear cells (PBMCs) of subjects chronically infected with HIV-1 in central Africa by four different dendritic cells targeted HIV gag p24 protein vaccines based on CRFO2_AG, C, B and MOSAIC HIV gag sequences, which are designed to address the problems associated with HIV-1 diversity.