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IAS2017 Sponsored Symposium: Coinfections associated with high mortality in severely immunocompromised HIV patients

Start date: 26 July 2017, 07:00
End date: 26 July 2017, 08:30
Location: Room 242
Type of event: International meeting
Scope: HIV

Sponsored by EDCTP in partnership with ANRS

Despite significant strides in HIV management, coinfections are often the direct cause of mortality in severely immunocompromised HIV-positive individuals in sub-Saharan Africa. Due partly to these patients’ immune status, such coinfections can result in unique public health challenges in diagnosis and treatment, especially in resource-limited settings with high multiple disease burden. Major obstacles to effective coinfection management include overlapping toxicities, altered treatment efficacy due to drug-drug interactions, difficulties in medication adherence, and difficulties/delays in diagnosis; for some diseases, there is also a paucity of diagnostic and treatment tools. The symposium will highlight recent advances in HIV/tuberculosis and HIV/cryptococcal coinfections, showcase EDCTP/ANRS-funded projects and present the funding strategy in this area. The following themes will be covered: (1) quantitative diagnostics, (2) advances in efficacious, low toxicity treatments and (3) implementation of treatment algorithms to reduce mortality.

Agenda

Download the agenda in PDF format

Programme booklet

Chairperson: Andrew Kambugu, Makerere University, Uganda

07:00  Brief introduction to EDCTP and ANRS: Description of ongoing projects and funding opportunitiesChristy Comeaux, European & Developing Countries Clinical Trials Partnership (EDCTP)François Dabis, French National Agency for Research on AIDS and Viral Hepatitis (ANRS)
07:10 Driving REduced AIDS-associated Meningo-encephalitis Mortality in routine care settings in Africa: Update on the DREAMM projectAngela Loyse, Meningitis Group, St George’s University of London
07:22 High Dose AMBISOME on a Fluconazole Backbone for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: A Randomised Controlled Non-inferiority TrialJoseph Jarvis, London School of Hygiene & Tropical Medicine
07:34 Decreasing mortality in HIV-infected adults with severe immune suppression: The STATIS (ANRS 12290) randomized trialFrançois-Xavier Blanc, Nantes University Hospital
07:46 Reducing mortality among advanced stage HIV-infected persons and the translation of a life saving package of care to inform scale-up in real-life settings in sub-Saharan AfricaSayoki Mfinanga, Muhimbili Medical Research Centre, National Institute for Medical Research (NIMR)
07:58 Discussion, led by Chair