Neglected infectious diseases

Neglected Infectious Diseases (NIDs, also known as Neglected Tropical Diseases) are a diverse group of diseases that affect an estimated 1.2 billion people worldwide. These diseases disproportionately affect the world’s poor, causing significant mortality and morbidity. Global investment into research and development of new products for NIDs is limited and there is an urgent need to develop new or improved products and to optimise the use of existing products in order to achieve disease elimination.

Neglected infectious diseases in the scope of EDCTP2*

Buruli ulcer, dengue, dracunculiasis (guinea-worm disease), echinococcosis, foodborne trematodiases, human African trypanosomiasis (sleeping sickness), leishmaniasis, leprosy (Hansen’s disease), lymphatic filariasis, mycetoma, onchocerciasis (river blindness), rabies, schistosomiasis, soil-transmitted helminthiases, taeniasis/cysticercosis, trachoma, yaws (endemic treponematoses)

* Based on the WHO list of neglected tropical diseases 2017; Chagas disease, chikungunya, chromoblastomycosis and other deep mycoses, scabies and other ectoparasites, and snakebite envenoming are currently not in the EDCTP scope.

EDCTP portfolio: Neglected infectious diseases

Collaborative clinical trials and clinical research (2014-2021)

Most projects are focused on therapeutic development and reformulation. Projects cover the key neglected infectious diseases affecting sub-Saharan Africa, including schistosomiasis, leishmaniasis, onchocerciasis, human African trypanosomiasis and leprosy. There is a strong focus on the development of tools to facilitate disease elimination, including new formulations of drugs for young children.