Advances in product development for effective prevention, treatment and management of co-infections and co-morbidities – 2018

Co-infections with several pathogens are frequent in sub-Saharan Africa and represent an important public health problem in many areas due to accelerated and/or complicated disease progression, resulting in increased mortality and morbidity. These co-infections can result in unique challenges in the treatment and prevention of disease, including increased drug toxicities and/or changes in the efficacy of interventions. The rise in the incidence of non-communicable diseases (NCDs) in sub-Saharan Africa and the necessity for long-term management of some poverty-related diseases and NCDs, often concurrently, adds to these complexities.

The purpose of this call for proposals is to support research for improvements in the prevention, treatment and/or clinical management of co-infections and co-morbidities in sub-Saharan Africa. Proposals must include at least one infection within the EDCTP2 scope.

Call identifier:  RIA2018CO

Preventing and delaying the development of diabetes in Africa: a randomised placebo-controlled double-blind phase III trial of metformin in HIV-infected persons with pre-diabetes

Liverpool School of Tropical Medicine (LSTM), Liverpool, United Kingdom, with partners from Norway, Spain, and Tanzania
Project coordinator: Prof. Shabbar Jaffar (LSTM)
Starting date: 01 April 2020
Duration: 57 months
EDCTP grant amount: EUR 3,992,974
Grant agreement: RIA2018CO-2513

Randomised controlled trial of preventive treatment of latent tuberculosis infection in patients with diabetes mellitus

Stichting Katholieke Universiteit  – Radboud UMC (RUMC), Nijmegen, the Netherlands, with partners from New Zealand, Tanzania, Uganda, and the United Kingdom
Project coordinator: Dr Reinout van Crevel (RUMC)
Starting date: 01 January 2020
Duration: 54 months
EDCTP grant amount: EUR 4,844,699
Grant agreement: RIA2018CO-2514

Vitamin D for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology: an individually randomised, double-blinded, placebo-controlled trial

London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom, with partners from Germany, the United Kingdom, Zambia, and Zimbabwe
Project coordinator: Prof. Rashida Ferrand (LSHTM)
Starting date: 01 January 2020
Duration: 60 months
EDCTP grant amount: EUR 3,943,982
Grant agreement: RIA2018CO-2512