Career Development Fellowships – 2017

Closed
Type of actionTraining & Mobility Action (TMA)
Open date03 August 2017, 11:00
Close date21 November 2017, 14:00
Budget€2.5 M
Funding levelUp to 100% of eligible costs

Expected number of grants: 17-19

Call identifier: 
TMA2017CDF


See the list of awarded projects


Expected number of grants: 17-19
Call identifier: 
TMA2017CDF

See the list of awarded projects

Description

Background

There is a severe shortage of opportunities for junior and mid-career researchers to acquire and develop clinical research skills in sub-Saharan Africa. Increased possibilities for individual training would enable talented scientists to establish themselves as independent researchers and team leaders at host institutions in sub-Saharan Africa.

Scope

The purpose of this Call for Proposals is to provide funding to actions that aim to support junior to mid-career researchers (‘fellows’) to train and develop their clinical research skills(1).

The objectives are:

  1. To promote career development and retention of postdoctoral researchers and postgraduate medical researchers in the research field and in sub-Saharan Africa;
  2. To equip the fellows with the ability to establish themselves as independent researchers and with the skills to initiate and manage their own research at host organisations in sub-Saharan Africa.

 

The proposed action should specifically enhance the ability of the fellow to design, plan and execute clinical biomedical and/or social science/ethics research projects within the scope of the EDCTP2 programme(2). The proposed training should include an independent research activity and a clear description of the skills that will be acquired by carrying out the research. Fellows with training activities involving clinical trials and related studies must ensure that studies are appropriately designed and good clinical practice (GCP)-compliant and that good manufacturing practice (GMP)-compliant investigational product(s) are available and guaranteed, and all sponsor responsibilities can be fulfilled by the host organisation (applicant legal entity where the fellow is employed) or product developer involved in the project. Individuals targeted by this Call for Proposals should have a track record of publications in peer-reviewed journals in their chosen area of research, a mentor who is an internationally recognised scientific leader working in sub-Saharan Africa, and a career development plan as part of the research proposal.

Application for a Career Development Fellowship must be submitted by an organisation with an established legal entity in sub-Saharan Africa (‘the applicant legal entity’) on behalf of the prospective fellow employed by that organisation. The grants are awarded to the host organisation with the explicit commitment that this organisation offers appropriate conditions for the fellow to direct and manage its funding for the duration of the fellowship.

Expected impact

Activities funded under this Call for Proposals will promote career progression, encourage entry and re-integration of African scientists trained abroad, and ensure the retention of postdoctoral and postgraduate researchers in their respective research fields and that the researchers develop into independent researchers and team leaders in sub-Saharan Africa. The progressive generation of independent researchers, re-entry of ones trained abroad and retention of those working in sub-Saharan Africa will ultimately contribute to creation of a critical mass of internationally recognised scientific leaders, institutions and networks that will sustain high quality research in sub-Saharan Africa. The career development fellowship grants will also contribute to reduce and reverse the brain drain of African scientist that moved out of or trained outside Africa by offering an opportunity to return to Africa and progress their career to establish themselves as independent researchers, thereby empowering them to assume a leadership role in clinical research and contributing to sustainable development.

Eligibility

  1. The applicant must be an organisation with an established legal entity in sub-Saharan Africa (the applicant legal entity).(3)
  2. The fellow must be employed or have guaranteed employment by the applicant legal entity (the host organisation) where they intend to remain working for a minimum of two years after the expiration of the grant.(3)
  3. Fellows must:(3)
  • be resident of or be willing to relocate to a sub-Saharan African country;
  • be either a graduate in a subject relevant to the EDCTP2 programme, with a PhD and up to five years’ relevant postdoctoral research experience, or a medical doctor with up to five years’ research experience;
  • have at least one publication in an international peer-reviewed journal;
  • not have been funded under this fellowship scheme before.(4)
  1. The requested EDCTP contribution per action shall not exceed € 150,000.
  2. The maximum fellowship duration shall be 36 months.

 

Notes:

  1. The Calouste Gulbenkian Foundation will support the EDCTP2 programme with a total contribution of up to € 265,000 to this Call for Proposals. This cash contribution is restricted in use by the EDCTP Association for funding participants in actions resulting from this Call for Proposals, which are legally established in Portuguese-speaking sub-Saharan African countries. The call evaluation and grant management is centrally managed by the EDCTP Association in line with the Rules for Participation of Horizon 2020.
  2. For the purpose of this call, PRDs include HIV/AIDS, malaria, tuberculosis and the following neglected infectious diseases (NIDs): dengue/severe dengue; rabies; human African trypanosomiasis (sleeping sickness); Leishmaniases; cysticercosis/taeniasis; dracunculiasis (guinea-worm disease); echinococcosis; foodborne trematodiases; lymphatic filariasis; mycetoma; onchocerciasis (river blindness); schistosomiasis; soil-transmitted helminthiases; Buruli ulcer; leprosy (Hansen disease); trachoma; yaws; diarrhoeal diseases, lower respiratory tract infections, as well as emerging infectious diseases of particular relevance for Africa, such as Ebola or yellow fever.
  3. Explanatory note: This additional condition for participation according to RfP Art. 9.5 is required due to the objectives of this Training & Mobility Action. It aims to support junior fellows in sub-Saharan Africa in line with the activities called for by the EU legislator (EDCTP2 basic act, Annex II, activity 1c). It contributes to the specific objectives of the EDCTP2 programme which calls, e.g., for cooperation with sub-Saharan Africa on building their capacity for conducting clinical trials in compliance with fundamental ethical principles, relevant legislations and international standards, and for extended cooperation with private partners (EDCTP2 basic act, Annex I, objectives 2b).
  4. Explanatory note: This additional condition for participation according to RfP Art. 9.5 is required due to the objectives of the EDCTP2 programme which requires that the capacity for conducting clinical trials in sub-Saharan Africa are built and strengthened (EDCTP2 basic act, Annex II). Allowing fellows in sub-Saharan Africa to only receive once a specific EDCTP2 fellowship will increase the number of different fellows supported and promoted under the EDCTP2 programme, and in turn strengthen more broadly the corresponding clinical research capacity in sub-Saharan Africa.

Procedure and application process

Submission and evaluation procedure

This is a single-stage application procedure. Proposals must be submitted by 21 November 2017 via EDCTPgrants. Evaluation results are expected to be made available by 16 April 2018.

The host organisation (applicant) must provide a support letter confirming that the organisation is supportive of the proposed action and willing through its financial and administrative systems to enable the fellow to direct independently the proposed action and manage its funding for the duration of the fellowship.

Evaluation, scoring and thresholds

Following an admissibility and eligibility check, letters of intent and full proposals are evaluated by external, independent experts. Proposals are evaluated according to the criteria Excellence, Impact and Implementation. Each criterion is scored between 0 and 5.

The following aspects are considered under the evaluation criteria:

 

  1. Excellence
  • Fit with the scope and objectives of the EDCTP2 Programme, the EDCTP strategic research agenda and the call topic description.
  • Importance, relevance/pertinence and clarity of the objectives.
  • Soundness of the concept and credibility of the proposed approach/methodology.
  • Suitability of the candidate, considering their track record, degree of independence and/or potential, and how the fellowship will further the individual’s career.
  • Quality of the project and its fit with the fellow’s expertise and career development plan, including acquired competencies and skills to be developed further.

 

  1. Impact
  • The extent to which the outputs of the proposed work would contribute, at the European, African and/or International level, to each of the expected impacts listed in the work plan under the relevant topic.
  • Likelihood to result in major advances in the field.
  • Contribution of the fellowship to the fellow’s clinical research skills and career development.
  • Contribution to strengthening clinical research capacity at the home or host organisation.
  • Effectiveness of the proposed measures to exploit and disseminate results generated during the fellowship (including management of IPR), to communicate the fellowship activities, and, where relevant, to manage clinical data.
  • Sustainability and retention of capacity post-award.

 

  1. Quality and efficiency of the implementation
  • Quality and effectiveness of the work plan, including extent to which the resources assigned to work packages are in line with their objectives and deliverables;
  • Appropriateness of the management structures and procedures, including risk and innovation management, and how responsibilities for research data quality and sharing, and security will be met.
  • Complementarity of the participants within the consortium, and the extent to which the consortium as whole brings together the necessary expertise.
  • Appropriateness of the allocation of tasks and resources, ensuring that all participants have a valid role and adequate resources in the project to fulfil that role.
  • Feasibility and appropriateness of the methods and project management to achieve the objectives within the timeframe of the grant.
  • Compliance with national and international standards of research, Good Clinical Practice, ethics and safety related issues.
  • Participants have the operational capacity, to carry out the proposed work, based on the competence and experience of the individual participant(s).
  • Suitability of the fellow’s home organisation to support the fellowship project.
  • Intention of the fellow’s home organisation to develop and commit to a career post-fellowship or re-integration plan.

 

Financial provisions

The call budget is €2.5 million.

The requested EDCTP contribution per project should not exceed €150,000. The funding level is up to 100% of eligible costs.

Grant agreement

The legal entity employing the successful fellow (‘host organisation’) is required to sign a grant agreement with EDCTP (EDCTP2 mono-beneficiary grant agreement with options for fellowships) within three months of receipt of the evaluation outcome letter.

Application process

  • The application must be submitted online via EDCTPgrants
  • Only registered users of EDCTPgrants system can apply for grants and therefore you are advised to register on the system as soon as possible

Documents and more information

Documents

More information

Projects funded under this call

Albuminuria and ACEI/ARB among HIV-patients
Career Development Fellow: Dr Mosepele Mosepele
Albuminuria among virally-suppressed HIV-infected patients in Botswana: longitudinal changes and association with inflammation and ACEI/ARB use in a clinical setting

University of Cape Town (UCT), Cape Town, South Africa
Starting date: 1 July 2019
Duration: 36 months
Grant amount: EUR 148,403
Grant agreement: TMA2017CDF-1928

Bethink TB
Career Development Fellow: Dr Virginie Rozot
NK and B cell determinants of immunity to Mycobacterium tuberculosis in humans

University of Cape Town (UCT), Cape Town, South Africa 
Starting date: 1 January 2019
Duration: 36 months
Grant amount: EUR 149,990
Grant agreement: TMA2017CDF-1905

CaNPSTS</strong >
Career Development Fellow: Dr Charles Drago Kato
Clinical evaluation of novel plasma biomarkers for stage diagnosis among sleeping sickness patients in Uganda

Makerere University, Kampala, Uganda
Starting date: 1 January 2019
Duration: 36 months
Grant amount: EUR 130,125
Grant agreement: TMA2017CDF-1887

ERAIN
Career Development Fellow: Dr Moses Masika
Emerging and re-emerging arboviral infections in Nairobi, Kenya

University of Nairobi, Nairobi, Kenya 
Starting date: 1 July 2019
Duration: 36 months
Grant amount: EUR 149,488
Grant agreement: TMA2017CDF-1865

FAST
Career Development Fellow: Dr Grace McHugh
Feasibility and acceptability of HIV self-testing in adolescents and young people

Biomedical Research and Training Institute (BRTI), Harare, Zimbabwe
Starting date: 1 October 2018
Duration: 28 months
Grant amount: EUR 141,745
Grant agreement: TMA2017CDF-1923

HighRif-C
Career Development Fellow: Hadija Semvua
Evaluation of pharmacokinetics and safety/tolerability of higher doses of rifampicin in children with newly diagnosed, uncomplicated tuberculosis

The Good Samaritan Foundation, Kilimanjaro Christian Medical Centre, Moshi, Tanzania 
Starting date: 1 July 2019
Duration: 36 months
Grant amount: EUR 149,621
Grant agreement: TMA2017CDF-1876

HypnoBio
Career Development Fellow: Dr Laurent Dembélé
Understanding the biology of Plasmodium vivax and Plasmodium ovale for the development of a field-based anti-hypnozoite drug screening model

Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali
Starting date: 1 December 2018
Duration: 36 months
Grant amount: EUR 148,000
Grant agreement: TMA2017CDF-1892

ID93-TBVaccine
Career Development Fellow: Dr Babatunde A. Adeagbo
Strategies to optimise the stability and bio-activity of a clinical tuberculosis vaccine

Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
Starting date: 1 October 2018
Duration: 46 months
Grant amount: EUR 149,999
Grant agreement: TMA2017CDF-1860

Informa-TB
Career Development Fellow: Dr Marisa Klopper
The role of Mycobacterium tuberculosis compensatory mutations in metabolic fitness via the structure and function of mycolic acids

Stellenbosch University, Stellenbosch, South Africa
Starting date: 1 December 2018
Duration: 36 months
Grant amount: EUR 150,000
Grant agreement: TMA2017CDF-1885

Latent HIV-1, Viral Suppress and Hope for HIV Cure
Career Development Fellow: Dr Edward Maina
Investigation of the impact of inducible, replication-competent latent HIV-1 as an impediment to HIV/AIDS cure in the context of sustained viral suppression

Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
Starting date: 1 May 2019
Duration: 36 months
Grant amount: EUR 149,500
Grant agreement: TMA2017CDF-1852

Mal-Brain Study
Career Development Fellow: Dr Symon Kariuki
Impact of RTS,S/AS01 vaccine and insecticide- treated bed nets on neurobehavioural impairment and school participation in children from rural Kenya

African Research Collaboration for Health Ltd, Kilifi, Kenya
Starting date: 1 March 2019
Duration: 36 months
Grant amount: EUR 149,623
Grant agreement: TMA2017CDF-1903

MOSAIC Career Development Fellow: Dr Charissa C. Naidoo
The longitudinal microbiome of South African tuberculosis patients, symptomatic culture-negative controls and healthy household contacts, and its association with treatment outcome

Stellenbosch University, Stellenbosch, South Africa
Starting date: 1 March 2019
Duration: 36 months
Grant amount: EUR 149,996
Grant agreement: TMA2017CDF-1914

Preg_multidrug
Career Development Fellow: Dr Tacilta Nhampossa
Understanding the determinants of the effectiveness of HIV control strategies targeting HIV-infected pregnant women in Mozambique

Fundação Manhiça, Maputo, Mozambique
Starting date: 1 February 2019
Duration: 36 months
Grant amount: EUR 149,098
Grant agreement: TMA2017CDF-1927

PENETRATE
Career Development Fellow: Dr C.G. Banda
Impact of standard antiretroviral therapy on the pharmacokinetic profile and placental penetration of piperaquine administered as dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria among HIV-infected pregnant women in Malawi

University of Malawi, Blantyre, Malawi 
Starting date: 1 September 2018
Duration: 36 months
Grant amount: EUR 149,999
Grant agreement: TMA2017CDF-1897

PERHAPS
Career Development Fellow: Dr Gbolahan Ajibola
Effects of preterm birth on HIV acquisition risk and antiretroviral prophylaxis safety in HIV-exposed infants in Botswana

Botswana-Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana 
Starting date: 1 November 2018
Duration: 18 months
Grant amount: EUR 75,431
Grant agreement: TMA2017CDF-1906

PRIMAQUINE Roll-out
Career Development Fellow: Dr Dominic Mosha
Monitoring safety of single low-dose primaquine co-administered with AL in routine healthcare practices: addressing potential implementation challenges and policy options for effective roll-out

Ifakara Health Institute (IHI), Dar es Salaam, Tanzania 
Starting date: 1 January 2019
Duration: 30 months
Grant amount: EUR 149,720
Grant agreement: TMA2017CDF-1878