Advances in product development for effective prevention, treatment and management of co-infections and co-morbidities – 2018

Co-infections with several pathogens are frequent in sub-Saharan Africa and represent an important public health problem in many areas due to accelerated and/or complicated disease progression, resulting in increased mortality and morbidity. These co-infections can result in unique challenges in the treatment and prevention of disease, including increased drug toxicities and/or changes in the efficacy of interventions. The rise in the incidence of non-communicable diseases (NCDs) in sub-Saharan Africa and the necessity for long-term management of some poverty-related diseases and NCDs, often concurrently, adds to these complexities.

The purpose of this call for proposals is to support research for improvements in the prevention, treatment and/or clinical management of co-infections and co-morbidities in sub-Saharan Africa. Proposals must include at least one infection within the EDCTP2 scope.

 

Call identifier:  RIA2018CO

5FC HIV-Crypto
Improved flucytosine formulation for the treatment of meningitis in advanced HIV disease

Drugs for Neglected Diseases Initiative (DNDi), Geneva, Switzerland, with partners from Luxembourg, Malawi, South Africa, Tanzania, and the United Kingdom
Project coordinator: Dr Isabela Ribeiro
Starting date: 01 July 2020
Duration: 54 months
EDCTP grant amount: EUR 3,537,000
Grant agreement: RIA2018CO-2516

DATURA
Determination of adequate tuberculosis regimen in adults and adolescents hospitalised with severe HIV-associated severe immune suppression (CD4 ≤ cells/𝝁L)

Institut national de la santé et de la recherche médicale (INSERM). Paris, France, with partners from Cameroon, France, Guinea, Norway, and Zambia
Project coordinator: Dr Didier Laureillard
Starting date: 01 May 2020
Duration: 54 months
EDCTP grant amount: EUR 4,567,140
Grant agreement: RIA2018CO-2515

META TRIAL
Preventing and delaying the development of diabetes in Africa: a randomised placebo-controlled double-blind phase III trial of metformin in HIV-infected persons with pre-diabetes

Liverpool School of Tropical Medicine (LSTM), Liverpool, United Kingdom, with partners from Norway, Spain, and Tanzania
Project coordinator: Prof. Shabbar Jaffar (LSTM)
Starting date: 01 April 2020
Duration: 57 months
EDCTP grant amount: EUR 3,992,974
Grant agreement: RIA2018CO-2513

PROTID
Randomised controlled trial of preventive treatment of latent tuberculosis infection in patients with diabetes melittus

Stichting Katholieke Universiteit  – Radboudumc (RUMC), Nijmegen, the Netherlands, with partners from New Zealand, Tanzania, Uganda, and the United Kingdom
Project coordinator: Dr Reinout van Crevel (RUMC)
Starting date: 01 January 2020
Duration: 54 months
EDCTP grant amount: EUR 4,844,699
Grant agreement: RIA2018CO-2514

VITALITY
Vitamin D for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology: an individually randomised, double-blinded, placebo-controlled trial

London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom, with partners from Germany, the United Kingdom, Zambia, and Zimbabwe
Project coordinator: Prof. Rashida Ferrand (LSHTM)
Starting date: 01 January 2020
Duration: 60 months
EDCTP grant amount: EUR 3,943,982
Grant agreement: RIA2018CO-2512