Strategic actions supporting large-scale clinical trials 2016

The purpose of this call for proposals is to support strategic clinical research activities which are part of a large-scale clinical trial that has the potential to achieve rapid advances in the clinical development of new or improved medical interventions against poverty-related infectious diseases.

Afri-KA-DIA
Towards an adopted, safe, effective combination treatment for African visceral leishmaniasis (Kala Azar) and improved diagnostic tools

Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland, with partners from Ethiopia, Kenya, The Netherlands, Spain, Sudan, Switzerland, Uganda, and the United Kingdom
Grant agreement: RIA2016S-1635
Project coordinator:
Dr Jorge Alvar (DNDi, Switzerland)
Starting date:
1 December 2017
Duration: 36 months
Total project value: EUR 11,588,438
EDCTP grant amount: EUR 5,560,748
Co-funding from: Amsterdam Medical Centre (AMC) and Nederlands Kanker Instituut (NKI) (both in The Netherlands), Instituto de Salud Carlos III (ISCIII; Spain) DNDi and FIND (both in Switzerland), London School of Hygiene & Tropical Medicine (LSHTM; United Kingdom).

Press release on launch (13 April 2018)

PZQ4PSAC
Phase III clinical trials and registration of a new praziquantel orally disintegrating tablet formulation suitable for preschool-aged children with schistosomiasis

Stichting Lygature (Lygature), Utrecht, the Netherlands, with partners from Côte d’Ivoire, Germany, Kenya, Switzerland, and United Kingdom
Grant agreement: RIA2016S-1641
Project coordinator:
 Dr Remco de Vrueh (Lygature, the Netherlands)
Starting date:
 1 February 2018
Duration: 24 months
Total project value: EUR 12,103,948
EDCTP grant amount: EUR 1,988,359
Co-funding from: Farmanguinhos (Brazil), Merck KgaA (Germany), GHIT Fund (Japan), Astella (Japan), Lygature (the Netherlands), Swiss TPH (Switzerland), Imperial College of Science, Technology and Medicine (United Kingdom).

Website Pediatric Praziquantel Consortium

TREATS
Tuberculosis reduction through expanded antiretroviral treatment and screening for active TB

London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom, with partners from France, Germany, Netherlands, South Africa, United Kingdom, and Zambia
Grant agreement: RIA2016S-1632
Project coordinator:
 Prof. Helen Ayles (LSHTM, United Kingdom)
Starting date:
1 November 2017
Duration: 48 months
Total project value: EUR 26,301,054
EDCTP grant amount: EUR 12,902,402
Co-funding from: International Initiative for Impact evaluation (3ie, international NGO), Evidence for HIV Prevention in Southern Africa / Department for International Development / Swedish International Development Agency (EHPSA, South Africa/DFID, United Kingdom/SIDA, Sweden), Qiagen GMBH (Germany), Delft Imaging Systems BV (the Netherlands), Medical Research Council – UK (MRC, United Kingdom), United States President’s Emergency Plan for AIDS Relief (PEPFAR, United States), National Institutes of Health (NIAID and NIMH, United States).

Website