Strategic actions supporting large-scale clinical trials (2017)

This Call for proposals is to support strategic actions (clinical research activities) that are part of a large-scale clinical trial with the potential to achieve rapid advances in the clinical development of new or improved medical interventions (drugs, diagnostics, vaccines, microbicides) for poverty-related diseases (PRDs).

CAP012 SAMBA Trial
CAPRISA 012: Phase I/II trial of subcutaneous administration of monoclonal broadly-neutralising antibodies

Centre for the Aids Programme of Research in South Africa (CAPRISA), Durban, South Africa, with partners from France, Netherlands, and Zambia
Project coordinator: Prof. Salim Abdool Karim (CAPRISA, Durban, South Africa)
Starting date:
 1 January 2019
Duration: 60 months
EDCTP grant amount: EUR 9,254,000
Grant agreement: RIA2017S-2008

ETEC Vaccine Efficacy
Field studies of an oral whole cell ETEC vaccine candidate in African toddlers and children: Assess efficacy and set parameters for pivotal phase III trials

Scandinavian Biopharma Holding AB (SBH), Solna, Sweden, with partners from Finland, Sweden, United Kingdom, and Zambia

Project coordinator: Mr Björn Sjöstrand (SBH, Sweden)
Starting date:
 1 January 2019
Duration: 48 months
EDCTP grant amount: EUR 7,368,180
Grant agreement: RIA2017S-2024

THECA
Effect of a novel typhoid conjugate vaccine in Africa: a multicentre study in Ghana and the Democratic Republic of the Congo

The Chancellor, Masters and Scholars of the University of Cambridge, Cambridge, United Kingdom, with partners from Bangladesh, Belgium, Burkina Faso, Democratic Republic of the Congo, France, Ghana, Madagascar, South Korea, and United States of America
Project coordinator: Dr Florian Marks (Cambridge University, United Kingdom)
Starting date:
 1 January 2019
Duration: 60 months
EDCTP grant amount: EUR 12,988,58
Grant agreement: RIA2017S-2027