//Celebrating the achievements of Dr Anna-Ursula Happel

Celebrating the achievements of Dr Anna-Ursula Happel

Dr Anna-Ursula Happel, a researcher at the University of Cape Town, South Africa, has made important strides in the field of maternal and child health through her EDCTP Career Development Fellowship. Her work particularly addresses the pressing health challenges faced by women living with HIV in sub-Saharan Africa, where the intersection of viral and bacterial infections in the female genital tract has implications for preterm birth risks.

Advancing scientific knowledge

Dr Happel’s research focused on understanding the complex interactions between the vaginal microbiome and the vaginal virome in pregnant women, particularly those living with HIV. Her study aimed to understand how these microbial communities influence adverse birth outcomes, such as preterm birth. This area of research is critical, as women with HIV are at a heightened risk for complications during pregnancy, impacting both maternal and infant health.

Key achievements and contributions

Throughout her fellowship, Dr Happel has achieved remarkable milestones, which include:

  • Promotions: Dr Happel was promoted from Postdoctoral Fellow to Junior Research Fellow in 2021 and subsequently to Senior Research Officer in 2024. These advancements are a testament to her dedication and exceptional contributions to her field.
  • Research Funding: She successfully secured a $300,000 research grant to investigate the infant gut microbiome, inflammation, and neurodevelopment, further establishing her as a leading researcher in maternal and child health.
  • Recognition: Dr Happel received the prestigious Emerging Global Leader (NIH K43) award, enabling her to solidify her position as a key figure in maternal and child health not only in Southern Africa but also on an international scale.
  • Publications: She co-authored 21 manuscripts during the fellowship, with publications in renowned journals such as Cell Host Microbe, Clinical Infectious Diseases, and Science Advances. Her work has contributed significantly to the body of knowledge regarding maternal health and HIV.
  • Mentorship: Dr Happel has played a pivotal role in mentoring several African female junior scientists, thus fostering the next generation of researchers in the field.
  • Leadership initiatives: She was accepted into the WomenLiftHealth Leadership programme, designed to support women in overcoming challenges and seizing opportunities for advancement in public health.

Building capacity and community engagement

Beyond her individual achievements, Dr Happel’s fellowship has contributed to the broader scientific community in South Africa. The project has provided training for an African PhD student, with an emphasis on empowering women in science, thereby addressing gender disparities in the field. Furthermore, the establishment of viral metagenomic data analysis capabilities within the country represents a significant step forward in scientific research, enhancing local expertise in this crucial area.

Future directions

The insights gained from Dr Happel’s research underscore the urgent need for further investigation into the vaginal virome’s role in reproductive health outcomes, particularly concerning preterm birth. As she continues her journey towards becoming an independent investigator, Dr Happel remains committed to improving health outcomes for women living with HIV. Her work not only advances scientific knowledge but also embodies a dedication to community health and the empowerment of future scientists.