Despite significant strides in HIV management, coinfections are often the direct cause of mortality in severely immunocompromised HIV-positive individuals in sub-Saharan Africa. Due partly to these patients’ immune status, such coinfections can result in unique public health challenges in diagnosis and treatment, especially in resource-limited settings with high multiple disease burden. Major obstacles to effective coinfection management include overlapping toxicities, altered treatment efficacy due to drug-drug interactions, difficulties in medication adherence, and difficulties/delays in diagnosis; for some diseases, there is also a paucity of diagnostic and treatment tools. The symposium will highlight recent advances in HIV/tuberculosis and HIV/cryptococcal coinfections, showcase EDCTP/ANRS-funded projects and present the funding strategy in this area. The following themes will be covered: (1) quantitative diagnostics, (2) advances in efficacious, low toxicity treatments and (3) implementation of treatment algorithms to reduce mortality.