The studies on NTDs funded by EDCTP funds can be explored in the online EDCTP grant portfolio. As an illustration a few projects are mentioned here:
Human African trypanosomiasis
The DiTECT-HAT study evaluates a range of tools that will make it easier to detect, treat and ultimately eradicate sleeping sickness. Efficient methods of detecting the parasite Trypanosoma brucei gambiense will be essential to eradication as they will enable monitoring of at-risk populations.
In partnership with the LRI, EDCTP has funded two studies on leprosy, PEOPLE (which seeks to find a new way to prevent the spread of leprosy) and PEP4LEP (which compares two approaches for screening and pre-emptively treating those at risk of leprosy infection).
The MoxiMultiDoseMod study aims to contribute to an accelerated onchocerciasis elimination through a paediatric dose-finding study. The project comprises two phase IIIb trials comparing efficacy and safety of single or annual and biannual moxidectin or ivermectin treatment and will develop mathematical models for moxidectin- and ivermectin-based elimination strategies to support country policy decisions.
EDCTP partners with the Japanese GHIT Funding agency in the fight against schistosomiasis, a common and debilitating parasitic disease among children. The ‘Praziquantel for Pre-School-Age Children’ study develops a version of an available drug treatment adapted for young children.
The LAMP4YAW project is evaluating a highly sensitive diagnostic test for yaws, a disfiguring and debilitating disease mostly affecting children. An effective drug is available but better diagnostics could accelerate eradication.