Targeting control and elimination of NIDs through product-focused implementation research – 2017

Type of actionResearch and Innovation Action (RIA)
Open date04 July 2017, 09:00
Close date02 November 2017, 13:00
Budget€11.2 M
Funding levelUp to 100% of eligible costs

EDCTP acknowledges cash contributions for this call from the Leprosy Research Initiative (LRI).

Expected number of grants: 3-5

Call identifier: RIA2017NIM

EDCTP acknowledges cash contributions for this call from the Leprosy Research Initiative (LRI).

Expected number of grants: 3-5
Call identifier: RIA2017NIM



Neglected Infectious Diseases (NIDs, also known as Neglected Tropical Diseases) are a diverse group of diseases that affect an estimated 1.2 billion people worldwide. These diseases disproportionately affect the world’s poor, causing significant mortality and morbidity. Global investment into research and development of new products for NIDs is limited and there is an urgent need to develop new or improved products and to optimise the use of existing products in order to achieve disease elimination.


The objective of this Call for Proposals is to provide funding for product-focused post-registration implementation studies for NIDs(1) in sub-Saharan Africa. Proposals that are in line with EDCTP’s strategic research agenda are encouraged.

Proposals should focus on implementation research studies to translate medical interventions (diagnostics, drugs for treatment and prevention) of proven efficacy into routine care, or on improving population coverage and access to the intervention, retention in care and/or adherence to the intervention. Proposals including randomised controlled trials (RCTs) are encouraged, although other study designs and methodologies can be used, where the design is justified and appropriate to provide robust evidence to support policy changes.

Proposals should include detailed plans for uptake of research results in international, regional or national guidelines and/or obtaining World Health Organisation (WHO) endorsement for improved disease management upon successful completion of the project.

Proposals focused exclusively on implementation of mass drug administration programmes or health systems strengthening are outside the scope of this Call.

EDCTP considers that proposals for activities of between 24 and 48 months and requesting funding of up to € 3 million would allow the specific challenges to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting another duration and/or funding.

Expected impact

Projects funded under this Call for Proposals shall contribute towards the achievement of the United Nations’ Sustainable Development Goal 3 (SDG3: ‘Ensure healthy lives and promote well-being for all at all ages’). Projects should generate robust scientific evidence for the effectiveness and optimisation of existing drugs or diagnostics that can be translated into health policy and clinical practice in sub-Saharan Africa.


Consortia comprising a minimum of three independent legal entities are eligible to apply. Two of the legal entities must be established in two different European Participating States(2) of the EDCTP Association and one of the legal entities must be established in a sub-Saharan African country(3). All three legal entities shall be independent of each other.

‘Sole participants’ formed by several legal entities (e.g. European Research Infrastructure Consortia, European Groupings of Territorial Cooperation, central purchasing bodies) are eligible if the above-mentioned minimum conditions are satisfied by the legal entities forming together the sole participant.


  1. For the purpose of this call, NIDs include: Buruli ulcer, cysticercosis/taeniasis, dengue, dracunculiasis, echinococcosis, foodborne trematodiases, leprosy (Hansen disease), human African trypanosomiasis, leishmaniasis, lymphatic filariasis, mycetoma, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthiases, trachoma, yaws.
  2. Legal entities in the following European countries: Austria, Denmark, Finland, France, Germany, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, and the United Kingdom.
  3. Legal entities in the following sub-Saharan African countries: Angola, Benin, Botswana, Burkina Faso, Burundi, Cameroon, Cape Verde, Central African Republic, Chad, Comoros, Democratic Republic of Congo, Republic of Congo, Djibouti, Eritrea, Ethiopia, Gabon, The Gambia, Ghana, Guinea, Guinea-Bissau, Ivory Coast, Kenya, Lesotho, Liberia, Madagascar, Malawi, Mali, Mauritania, Mauritius, Mozambique, Namibia, Niger, Nigeria, Rwanda, São Tomé & Príncipe, Senegal, Seychelles, Sierra Leone, Somalia, South Sudan, South Africa, Sudan, Swaziland, Tanzania, Togo, Uganda, Zambia and Zimbabwe.

Procedure and application process

Submission and evaluation procedure

This is a single-stage application procedure. Proposals must be submitted by 2 November 2017 via EDCTPgrants. Evaluation results are expected to be made available by 14 March 2018.

Evaluation, scoring and thresholds

Following an admissibility and eligibility check, letters of intent and full proposals are evaluated by external, independent experts. Proposals are evaluated according to the criteria Excellence, Impact and Implementation. Each criterion is scored between 0 and 5.

The following aspects are considered under the evaluation criteria:


  1. Excellence
  • Fit with the scope and objectives of the EDCTP2 Programme, the EDCTP strategic research agenda and the call topic description.
  • Importance, relevance/pertinence and clarity of the objectiv
  • Soundness of the concept and credibility of the proposed approach/methodology.
  • Importance of the question being addressed and the rationale/need for the proposed clinical trial(s) or research study now.
  • Excellence and appropriateness of the clinical trial design, including the proposed location(s) of the trial.
  • Extent that the proposed trial will advance the field. In particular, how it differs from or complements any relevant planned, ongoing or recently completed trials internationally.
  • Appropriate consideration of interdisciplinary approaches, and where relevant, use of stakeholder knowledge


  1. Impact
  • The extent to which the outputs of the proposed work would contribute, at the European, African and/or International level, to each of the expected impacts listed in the work plan under the relevant topic.
  • Likelihood to result in major advances in the field.
  • Advancing the clinical development of new and improved products.
  • Generalisability of the trial/study results beyond the immediate research setting in a way that will maximise the impact of the results.
  • Contribution to improved disease management and prevention through changes in policy, with the ultimate goal of improving public health.
  • Contribution to strengthening the capacity in sub-Saharan Africa to conduct clinical trials.
  • Effectiveness and quality of the proposed measures to exploit and disseminate the project results (including management of IPR) to communicate the project activities to different target audiences, and to manage research data


  1. Quality and efficiency of the implementation
  • Quality and effectiveness of the work plan, including extent to which the resources assigned to work packages are in line with their objectives and deliverables;
  • Appropriateness of the management structures and procedures, including risk and innovation management, and how responsibilities for research data quality and sharing, and security will be met.
  • Complementarity of the participants within the consortium, and the extent to which the consortium as whole brings together the necessary expertise.
  • Appropriateness of the allocation of tasks and resources, ensuring that all participants have a valid role and adequate resources in the project to fulfil that role.
  • Feasibility and appropriateness of the methods and project management to achieve the objectives within the timeframe of the grant.
  • Compliance with national and international standards of research, Good Clinical Practice, ethics and safety related issues.
  • Participants have the operational capacity, to carry out the proposed work, based on the competence and experience of the individual participant(s).
  • Competence of the participants and their investigators in conducting trials according to international standards of Good Clinical Practice (ICH-GCP).
  • Involvement of sub-Saharan African researchers in the scientific leadership of the clinical trial.
  • Arrangements and plans to take forward clinical development of the products under evaluation (where applicable).


Financial provisions

The call budget is € 11.2 million.

The funding level is up to 100% of eligible costs.

Grant agreement

The Coordinator is required to sign a grant agreement with EDCTP (EDCTP2 multi-beneficiary grant agreement) within three months of receipt of the evaluation outcome letter. All participants in the action must sign a consortium agreement prior to signature of the grant agreement.

Application process

  • The application must be submitted online via EDCTPgrants
  • Only registered users of EDCTPgrants system can apply for grants and therefore you are advised to register on the system as soon as possible

Documents and more information

More information

Projects awarded under this call

Impact of increased praziquantel frequency on childhood fibrosis in persistent schistosomiasis morbidity hotspots

Chancellor, Masters and Scholars of the University of Cambridge (UCAM), Cambridge, United Kingdom with partners from Denmark, Uganda, and the United Kingdom
Project coordinator: Dr Shona Wilson (UCAM), United Kingdom
Starting date: 1 August 2018
Duration: 48 months
Grant amount: EUR 3,030,929
Grant agreement: RIA2017NIM-1842
Go to website

Chemoprophylaxis for leprosy: comparing the effectiveness and feasibility of a skin camp intervention to a health centre-based intervention. An implementation trial in Mozambique, Ethiopia and Tanzania

Nederlandse Stichting voor Leprabestrijding (NLR), Amsterdam, the Netherlands, with partners from Ethiopia, Germany, Mozambique, the Netherlands, and Tanzania
Project coordinator: Ms. Liesbeth Mieras (NLR), the Netherlands
Starting date: 1 October 2018
Duration: 52 months
Grant amount: EUR 3,198,356
Grant agreement: RIA2017NIM-1839
Go to project website

Post exposure prophylaxis for leprosy in the Comoros and Madagascar

Prins Leopold Instituut voor Tropische Geneeskunde (ITM), Antwerp, Belgium, with partners from Belgium, France, Madagascar, and the Netherlands
Project coordinator: Prof. Bouke de Jong (ITM), Belgium
Starting date: 1 September 2018
Duration: 48 months
Grant amount: EUR 2,999,479
Grant agreement: RIA2017NIM-1847
Project website