The Trials of Excellence in Southern Africa (TESA) project coordinator, Dr Francisco Saúte, and project manager, Mr Rodrigues Matcheve, visited the EDCTP Africa Office on 20 September 2022 as they commenced a three-day site visit to TESA partners based in Cape Town, South Africa. The objective of the meeting was to discuss the operations of the TESA consortium and implementation progress of TESA-related EDCTP Participating States’ Initiated Activities (PSIA) supported projects: TESA Data Management Center Accreditation Project, supported by Fundação para a Ciência e Tecnologia (Portugal), and TAGENDI Female PhD Fellowship Programme, funded by the UK Department of Health and Social Care. The strategic direction of the consortium as EDCTP2 transitions to Global Health EDCTP3 Joint Undertaking was also discussed.